Retatrutide
Better Med Spa’s retatrutide program delivers a once-weekly triple-agonist peptide (GIP/GLP-1/glucagon) designed to reduce appetite, increase fat burning, and improve metabolic markers. Offered under a non-FDA–approved waiver, this advanced therapy includes physician oversight, labs, and integrated wellness support for qualified clients seeking aggressive, research-backed weight loss.
How It Works
Retatrutide is a triple hormone receptor agonist that targets GIP, GLP-1, and glucagon receptors, key pathways that regulate appetite, blood sugar, and energy expenditure. By slowing gastric emptying, enhancing glucose-dependent insulin release, suppressing glucagon, and modestly increasing energy burn, it has produced dose-dependent weight loss exceeding 20% of baseline body weight in phase 2 obesity trials. At Better Med Spa, retatrutide is positioned as an advanced peptide protocol: clients complete an informed consent waiver, undergo baseline labs, and follow a carefully titrated dosing schedule with ongoing monitoring and lifestyle coaching.
What It Targets
Retatrutide is designed to address:
- Significant overweight or obesity where rapid, meaningful weight loss is desired under medical supervision.
- Persistent hunger, large portions, and cravings that limit progress with diet and exercise alone.
- Central and visceral fat that drives cardiometabolic risk and affects body shape and confidence.
- Metabolic dysfunction such as elevated blood sugar, insulin resistance, and obesity-related risk factors.
- Fatty liver patterns (MASLD) in appropriate clients, where trials show retatrutide can reduce liver fat content.
- Plateaus after GLP-1 or dual-agonist medications for clients ready to explore an escalated, research-driven option.
Benefits
Experience the ultimate all-in-one solution:
- Triple agonism (GIP, GLP-1, glucagon) engages multiple pathways for appetite control, glycemic balance, and increased energy expenditure beyond standard GLP-1–only medications.
- Phase 2 data show substantial, dose-dependent weight loss, with higher doses averaging more than 20% body-weight reduction at around 48 weeks.
- Improvements in metabolic markers, including HbA1c, fasting glucose, blood pressure, waist circumference, and liver fat in studied cohorts.
- Once-weekly injections that fit a modern, peptide-style protocol with minimal disruption to a busy lifestyle.
- Delivered under a structured informed-consent framework, emphasizing transparency about non-FDA status, compounding and sourcing, and individualized risk–benefit assessment.
- Integrated with Better Med Spa’s high-touch ecosystem: nutrition support, accountability check-ins, body-contouring, and K-Beauty facials that align outer appearance with internal metabolic change.
Experience the best in aesthetic and wellness care at Better Med Spa. Our personalized treatments are tailored to you, designed to help you look and feel your absolute best with confidence and ease.
Questions?
We're here to answer your questions and provide the best services for your needs.
What is retatrutide and why is it considered “advanced”?
Retatrutide is a once-weekly triple hormone receptor agonist that activates GIP, GLP-1, and glucagon receptors to simultaneously reduce appetite, improve blood sugar, and increase energy expenditure. Early trials classify it as an advanced anti-obesity peptide because its degree of weight loss and metabolic impact appears greater than many current GLP-1–only or dual-agonist medications.
Is retatrutide FDA-approved, and what does the waiver mean?
Retatrutide is not yet FDA-approved for obesity treatment or routine clinical use; it is still under investigation in phase 2–3 trials. At Better Med Spa, retatrutide is offered only under a non-FDA–approved informed consent waiver that explains its investigational status, potential risks, benefits, and alternatives so clients can make a fully informed decision before starting.
Who is a good candidate for retatrutide at Better Med Spa?
Ideal candidates have significant weight to lose, obesity-related risk factors, and a readiness to pair medication with nutrition, movement, and regular monitoring. Each client completes a detailed medical intake, lab work, and consultation to rule out contraindications and to confirm that a non-FDA peptide protocol is clinically appropriate and aligned with personal risk tolerance.
What side effects and risks should I know about?
Gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation are the most commonly reported side effects and tend to be dose-related. Trials also report heart rate increases and potential concerns with rapid weight loss, including gallbladder issues and impacts on lean mass, which is why dosing, labs, and symptom tracking are built into Better Med Spa’s protocol.
How does Better Med Spa support clients on retatrutide?
Clients are enrolled in a structured program that includes baseline and follow-up labs, scheduled check-ins, and access to nutrition and lifestyle coaching to protect muscle, mood, and long-term results. Many choose to bundle retatrutide with memberships that include body-contouring, lymphatic support, and high-performance K-Beauty facials, aligning medical weight loss with skin quality, body shape, and overall confidence.